1. 5-Amino-1MQ 10mg
2. 5-Amino-1MQ 50mg
3. ACE-031 1mg
4. ACTH 1-39 5mg
5. Adamax 5mg
6. AHK-Cu 50mg
7. AICAR 50mg
8. AICAR 100mg
9. AOD-9604 5mg
10. AOD-9604 10mg
11. Alprostadil 20mcg
12. Amylin 5mg
13. Angiotensin (1–7) 5mg
14. ARA-290 10mg
15. Bimagrumab 5mg
16. Botulinum Toxin 100IU
17. BPC-157 10mg
18. BPC-157 20mg
19. BPC-157 5mg + TB-500 5mg
20. BPC-157 10mg + TB-500 10mg
21. Bronchogen 20mg
22. Cagrilintide 10mg
23. Cagrilintide 20mg
24. Cardiogen 20mg
25. Cartalax 20mg
26. CBL-514 10mg
27. CBL-514 20mg
28. CBL-514 30mg
29. Cerebrolysin 60mg
30. Cerlankin 2mg
31. CGRP (Calcitonin Gene-Related Peptide) 1mg
32. CJC-1295 with DAC 5mg
33. CJC-1295 with DAC 10mg
34. CJC-1295 with DAC 5mg + Ipamorelin 5mg
35. CJC-1295 without DAC 5mg
36. CJC-1295 without DAC 10mg
37. CJC-1295 without DAC 5mg + Ipamorelin 5mg
38. Chonluten 20mg
39. Cortagen 20mg
40. Crystagen 20mg
41. CT-1 Cardiotrophin-1 5mg
42. Dermorphin 5mg
43. Dihexa 5mg
44. DSIP 5mg
45. Dulaglutide 5mg
46. Elabela Apelin 5mg
47. Enfuvirtide 90mg
48. Epithalon 5mg
49. Epithalon 40mg
50. Epithalon 50mg
51. EPO 3000IU
52. FGF21 10mg
53. Follistatin-344 1mg
54. FOXO4 10mg
55. GHK-Cu 50mg
56. GHK-Cu 100mg
57. Ghrelin 10mg
58. GHRP-2 5mg
59. GHRP-6 5mg
60. Glucagon 1mg
61. Glutathione 1500mg
62. Gonadorelin Acetate 2mg
63. Goserelin 10mg
64. GLOW BPC-157 10mg + GHK-Cu 50mg + TB-500 10mg
65. HGH 191AA 15IU
66. HGH 191AA 36IU
67. HGH Fragment 176-191 10mg
68. HGH Fragment 176-191 15mg
69. HMG (Human Menopausal Gonadotropin) 75IU
70. Humanin 10mg
71. Hyaluronic Acid 5mg
72. Hexarelin Acetate 2mg
73. Hexarelin Acetate 5mg
74. IGF-1 LR3 1mg
75. Ipamorelin 5mg
76. Ipamorelin 10mg
77. Kisspeptin-10 5mg
78. Kisspeptin-10 10mg
79. KLOW BPC-157 10mg + GHK-Cu 50mg + TB-500 10mg + KPV 10mg
80. KPV 10mg
81. Leuprolide Acetate 10mg
82. Liraglutide 5mg
83. Livagen 20mg
84. LL-37 5mg
85. Lysyl Oxidase 30mg
86. Matrixyl 10mg
87. Mazdutide 10mg
88. Melanotan I 10mg
89. Melanotan II 10mg
90. Melatonin 10mg
91. MGF 2mg
92. MOTS-c 10mg
93. MOTS-c 40mg
94. NAD+ 100mg
95. NAD+ 500mg
96. NAD+ 1000mg
97. Nesiritide 5mg
98. Neuropeptide Y (NPY) 10mg
99. Ovagen 20mg
100. Oxytocin Acetate 5mg
101. Oxytocin Acetate 10mg
102. P21 5mg
103. P21 10mg
104. PACAP 5mg
105. Pancragen 20mg
106. PE 22-28 10mg
107. PEG-MGF 2mg
108. Pinealon 5mg
109. Pinealon 10mg
110. Pinealon 20mg
111. PNC-27 5mg
112. PNC-27 10mg
113. Prostamax 20mg
114. PT-141 10mg
115. PTH Fragments 10mg
116. Relamorelin 5mg
117. Retatrutide 10mg
118. Retatrutide 20mg
119. Retatrutide 30mg
120. Retatrutide 40mg
121. Retatrutide 60mg
122. Retatrutide 5mg + Cagrilintide 5mg
123. Selank 5mg
124. Selank 10mg
125. Semaglutide 5mg + Cagrilintide 5mg
126. Semax 5mg
127. Sermorelin 5mg
128. SLU-PP-332 10mg
129. SNAP-8 10mg
130. SS-31 10mg
131. SS-31 50mg
132. Survodutide 10mg
133. TB-500 10mg
134. TB-500 (FRAG) 10mg
135. Teduglutide 5mg
136. Teriparatide 10mg
137. Tesamorelin 5mg
138. Tesamorelin 10mg
139. Tesamorelin 20mg
140. Tesamorelin 5mg + Ipamorelin 5mg
141. Tesofensine 1mg
142. Testagen 20mg
143. Thymalin 10mg
144. Thymosin Alpha-1 5mg
145. Thymosin Alpha-1 10mg
146. Treprostinil 5mg
147. Vesugen 20mg
148. VIP 5mg
149. VIP 10mg
150. Vilon 20mg
5-Amino-1-methylquinolinium (5-AMQ or 5-Amino-1MQ) is described as a potent inhibitor of the NNMT enzyme, with scientific relevance and potential application in in vitro experimental studies focused on metabolic disorders and increased energy expenditure.
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5-Amino-1MQ is a synthetic compound that acts as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Inhibition of this enzyme is associated with the regulation of intracellular levels of NAD⁺ and SAM, influencing energy production and metabolic pathways related to lipid metabolism in experimental models.
Preclinical laboratory studies indicate effects on processes related to weight management, muscle mass maintenance, mitochondrial activity, and pathways associated with cellular aging. This methylquinolinium derivative therefore emerges as a compound of scientific interest for fundamental research on metabolism and cellular longevity mechanisms.
Important Information
| Property | Value |
| Molecular Formula | C10H11N2 |
| Molecular Weight | 159.21 g/mol |
| PubChem CID | 950107 |
| Synonyms | 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZMJBCEIHNOWCMC-UHFFFAOYSA-O, STL196667 |
Main Structure of 5-amino-1MQ Peptide
Source: PubChem
Peptides undergo a lyophilization (freeze-drying) process, a technique that enhances stability and shelf life while preserving purity and molecular structure during storage. No fillers are used during this process.
Biopelabs states: this material is provided exclusively as a chemical input for research purposes. Its use is restricted to in vitro assays and experimental laboratory activities. The information presented is strictly for informational and educational purposes. Handling must be performed only by qualified professionals. This product is not classified as a drug, food, or cosmetic and must not be used, marketed, or represented as such.
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule belonging to the class of methylquinolinium derivatives. Structurally, it is characterized by a quinolinium core with an amino substitution at position 5 and a methyl group at position 1. This compound has been widely investigated in preclinical research due to its specific interaction with enzymes involved in cellular metabolism.
Experimental studies identify 5-Amino-1MQ as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme associated with metabolic, epigenetic, and cellular energy processes.
The primary mechanism investigated for 5-Amino-1MQ involves the inhibition of NNMT, an enzyme responsible for the methylation of nicotinamide. This pathway directly influences NAD⁺ (nicotinamide adenine dinucleotide) metabolism, an essential cofactor for redox reactions, DNA integrity maintenance, and regulation of gene expression.
Suppression of NNMT activity has been associated with significant changes in interconnected metabolic pathways, including:
In preclinical models, exposure of murine adipocytes to 5-Amino-1MQ resulted in a concentration-dependent increase in intracellular NAD⁺ levels, suggesting a direct impact on metabolic homeostasis and cellular function.
In the context of metabolic disorder research, 5-Amino-1MQ has been evaluated in experimental models of diet-induced obesity. Data indicate consistent reductions in body weight, white adipose tissue mass, and adipocyte size, without significant changes in food intake.
These findings suggest that the observed metabolic effects are not related to appetite suppression, but rather to the direct modulation of pathways associated with lipogenesis and energy storage. This profile makes 5-Amino-1MQ a compound of interest in research focused on energy metabolism and experimental obesity.
Beyond metabolic applications, 5-Amino-1MQ has been studied in preclinical oncological research, particularly due to its influence on cellular epigenetic and energy mechanisms.
In studies involving cancer-associated fibroblasts (CAFs), NNMT inhibition by 5-Amino-1MQ demonstrated:
In animal models, these effects were associated with reduced tumor cell proliferation, positioning the compound as an object of interest in investigations focused on isolated or combined experimental strategies.
From a pharmacological perspective, 5-Amino-1MQ exhibits good cellular permeability, a characteristic that supports its use in various experimental models. However, aspects related to metabolic stability, tissue distribution, and elimination remain under investigation.
Additional in vitro and in vivo studies are necessary to further understand its pharmacokinetic and pharmacodynamic profile, particularly regarding tissue selectivity and minimization of off-target effects.
5-Amino-1MQ represents a compound of high interest in contemporary scientific research, especially in studies related to energy metabolism, epigenetic regulation, and tumor biology. Its role as a selective NNMT inhibitor positions it as a valuable tool for investigating complex metabolic and cellular mechanisms.
The use of 5-Amino-1MQ remains restricted to research purposes, and it is essential that any investigation follows rigorous scientific protocols and applicable regulatory standards.
Conlon, N., & Ford, D. (2022). A systemic approach to NAD⁺ restoration... Biochemical Pharmacology, 114946. https://doi.org/10.1016/j.bcp.2022.114946
Myong, S., Nguyen, A., & Challa, S. (2024). Biological functions and therapeutic potential of NAD⁺ metabolism in gynecologic cancers. Cancers, 16. https://doi.org/10.3390/cancers16173085
Li, X., Pi, Y., Chen, Y., Zhu, Q., & Xia, B. (2022). Nicotinamide N-methyltransferase: a promising biomarker and target for human cancer therapy. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.894744
Liu, J., Deng, Z., Zhu, X., Zeng, Y., Guan, X., & Li, J. (2021). Functions of nicotinamide N-methyltransferase in obesity and type 2 diabetes. BioMed Research International, 2021. https://doi.org/10.1155/2021/9924314
This content was reviewed by Dr. Ky H. Le, MD. Dr. Ky H. Le is a family physician based in Aiea, Hawaii. He earned his medical degree from St. George's University School of Medicine and has been practicing for over 20 years. He has expertise in the treatment of obesity, diabetes, hypertension, and high blood pressure, among other conditions. Dr. Ky H. Le accepts Medicare, Aetna, Humana, Blue Cross, and United Healthcare.
Ref.: https://health.usnews.com/doctors/ky-le-371599#expertise
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| Weight | 40 g |
|---|---|
| Dimensions | 7 × 3,6 × 8 cm |
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